entete
         
GROUP since 2004

Original Articles
 

 
D.A. Koutsouras, R. Perrier, A. Villaroel-Marquez, A. Pirog, E. Pedraza, E. Cloutet, S. Renaud, M. Raoux, G.G. Malliaras, J. Lang, Simultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays, Materials Science and Engineering: C, (IN PRESS)

Hastoy, B., P. A. Scotti, A. Milochau, Z. Fezoua-Boubegtiten, J. Rodas, R. Megret, B. Desbat, M. Laguerre, S. Castano, D. Perrais, P. Rorsman, R. Oda and J. Lang (2017). A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis. Scientific Reports 7(1): 2835.

Semplici, F., A. Mondragon, B. Macintyre, K. Madeyski-Bengston, A. Persson-Kry, S. Barr, A. Ramne, A. Marley, J. McGinty, P. French, H. Soedling, R. Yokosuka, J. Gaitan, J. Lang, S. Migrenne-Li, E. Philippe, P.L. Herrera, C. Magnan, G. da Silva Xavier, and G.A. Rutter. Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production. Diabetologia2016, 59:1938-47


Solomou, A., E. Philippe, P. Chabosseau, S. Migrenne-Li, J. Gaitan, J. Lang, C. Magnan, and G.A. Rutter.  Over-expression of Slc30a8/ZnT8 selectively in the mouse alpha cell impairs glucagon release and responses to hypoglycemia. Nutr Metab (Lond). 2016, 13:46.

Pedraza, E., Karajić A, Raoux M, Perrier R, Lebreton F, Arbault S, Gaitan J, Renaud S, Kuhn A, Lang, J (in press). Guiding pancreatic beta-cells to target electrodes in a whole-cell biosensor for diabetes.Lab Chip, 2015, DOI: 10.1039/C5LC00616C.


Lebreton F, Pirog A, Belouah I, Bosco D, Berney T, Meda P, Bornat Y, Catargi B, Renaud S, Raoux M, Lang J (in press) Slow potentials encode intercellular coupling and insulin demand  in pancreatic beta cells. Diabetologia

M. Raoux, P. Vacher, J. Papin, A. Picard, E. Kostrzewa, A. Devin, J. Gaitan, I. Limon, M. J. Kas, C. Magnan , J. Lang (2015). Multilevel control of glucose homeostasis by adenylyl cyclase 8Diabetologia. 58:749-757

H. Dou, C.Wang, X. Wu, L. Yao, X. Zhang, S. Teng, H. Xu, B. Liu, Q. Wu, Q. Zhang, M. Hu, Y. Wang, L. Wang, Y. Wu, S. Shang, X. Kang, L. Zheng, J. Zhang, Raoux M., Lang J., Q. Li, J. Su, X. Yu, L. Zhou. (2015) Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 58:324-33

Schaepelynck P, Riveline JP, Renard E, Hanaire H, Guerci B, Baillot-Rudoni S, Sola-Gazagnes A, Catargi B, Fontaine P, Millot L, Martin JF, Tachouaft H, Jeandidier N, Group E (2014) Assessment of a new insulin preparation for implanted pumps used in the treatment of type 1 diabetes. Diabetes Technology & Therapeutics 16: 582-589

Tarus D, Hachet E, Messager L, Catargi B, Ravaine V, Auzely-Velty R (2014) Readily Prepared Dynamic Hydrogels by Combining Phenyl Boronic Acid- and Maltose-Modified Anionic Polysaccharides at Neutral pH. Macromolecular Rapid Communications. 35:  2089-95

Pinaud F, Geisel K, Masse P, Catargi B, Isa L, Richtering W, Ravaine V, Schmitt V (2014) Adsorption of microgels at an oil-water interface: correlation between packing and 2D elasticity. Soft Matter 10: 6963-6974

Milochau, A., Lagrée, V., Bennassy, M.N., Papin, J., Lajoix, A., Chaignepain, S., Garcia-Arcos, I., Schmitter, J.M., Ochoa, B. and Lang, J. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic ß-cells. FEBS Lett.  2014, 588:2217-2222.

Nguyen, Q.V., Caro, A., Raoux, M., Quotb, A., Floderer, J.B., Bornat, Y., Renaud, S. and Lang, J. (2013). A novel bioelectronic glucose sensor to process distinct electrical activities of pancreatic beta-cells. Conf Proc IEEE Eng Med Biol Soc 2013, 172-175. 


A. Quotb, Bornat Y, Raoux M, Lang J, Renaud S. NeuroBetaMed: A re-configurable wavelet-based event detection circuit for in vitro biological signals. 2012 IEEE International Symposium on Circuits and Systems (ISCAS), Seoul, Korea (South). 2012.

Raoux, M.,  Bornat, Y., Quotb, A., Catargi, B., Renaud, S. and  Lang , J.  Non-invasive long-term and real-time analysis of endocrine cells on micro-electrode arrays. J. Physiol. 2012, 590:1085-1092.

Schlumberger M, Catargi B, Borget I, Deandreis D, Zerdoud S, , Bridji B, Bardet S, Leenhardt L, Bastie D, M.D., Schvartz C, Vera P, Morel O, Benisvy D, Bournaud C, Bonichon F, Dejax C, Toubert ME, Leboulleux S, Ricard M, Benhamou E, and the TUTHYREF Network for the ESTIMABL Equivalence Trial: (2012). Strategies of Radioiodine Ablation in Low-risk Thyroid Cancer Patients. New Engl J Med, 366: 1663-1673

Nguyen, Q.V., Caro, A., Raoux, M., Quotb, A., Floderer, J.B., Bornat, Y., Renaud, S. and Lang, J. (2013). A novel bioelectronic glucose sensor to process distinct electrical activities of pancreatic beta-cells. Conf Proc IEEE Eng Med Biol Soc 2013, 172-175.

Gerstein HC, Bosch J, Dagenais GR, et al. (2012) Basal insulin and cardiovascular and other outcomes in dysglycemia. New Eng J Med 367: 319-328

Bosch J, Gerstein HC, Dagenais GR, et al. (2012) n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. New Eng J Med 367: 309-318


A. Quotb, Bornat Y, Raoux M, Lang J, Renaud S. NeuroBetaMed: A re-configurable wavelet-based event detection circuit for in vitro biological signals. 2012 IEEE International Symposium on Circuits and Systems (ISCAS), Seoul, Korea (South). 2012.

Raoux, M.,  Bornat, Y., Quotb, A., Catargi, B., Renaud, S. and  Lang , J.  Non-invasive long-term and real-time analysis of endocrine cells on micro-electrode arrays. J. Physiol. 2012, 590:1085-1092.

A. Quotb, Bornat Y, Raoux M, Lang J, Renaud S. NeuroBetaMed: A re-configurable wavelet-based event detection circuit for in vitro biological signals. 2012 IEEE International Symposium on Circuits and Systems (ISCAS), Seoul, Korea (South). 2012.

Riveline JP, Schaepelynck P, Chaillous L, Renard E, Sola-Gazagnes A, Penfornis A, Tubiana-Rufi N, Sulmont V, Catargi B, Lukas C, Radermecker RP, Thivolet C, Moreau F, Benhamou PY, Guerci B, Leguerrier AM, Millot L, Sachon C, Charpentier G, Hanaire H; for the EVADIAC Sensor Study Group. 2012. Assessment of Patient-Led or Physician-Driven Continuous Glucose Monitoring in Patients With Poorly Controlled Type 1 Diabetes Using Basal-Bolus Insulin Regimens: A 1-year multicenter study. Diabetes Care. 2012 Mar 28.

Vergès B, Avignon A, Bonnet F, Catargi B, Cattan S, Cosson E, Ducrocq G, Elbaz M, Fredenrich A, Gourdy P, Henry P, Lairez O, Leguerrier AM, Monpère C, Moulin P, Vergès-Patois B, Roussel R, Steg G, Valensi P. 2011. Consensus statement on the care of the hyperglycaemic/diabetic patient during and in the immediate follow-up of acute coronary syndromeDiabetes Metab. Epub

C. Ancla, V. Lapeyre, I. Gosse, B. Catargi and V. Ravaine, 2011, Designed glucose-responsive microgels with selective shrinking behavior, Langmuir, 27, 12693-701

G. Charpentier, P. Y. Benhamou, D. Dardari, A. Clergeot, S. Franc, P. Schaepelynck-Belicar, B. Catargi, V. Melki, L. Chaillous, A. Farret, J. L. Bosson and A. Penfornis, 2011, The Diabeo software enabling individualized insulin dose adjustments combined with telemedicine support improves HbA1c in poorly controlled type 1 diabetic patients: a 6-month, randomized, open-label, parallel-group, multicenter trial (TeleDiab 1 Study), Diabetes Care, 34, 533-9

P. Schaepelynck, E. Renard, N. Jeandidier, H. Hanaire, C. Fermon, S. Rudoni, B. Catargi, J. P. Riveline, B. Guerci, L. Millot, J. F. Martin and A. Sola, 2011, A recent survey confirms the efficacy and the safety of implanted insulin pumps during long-term use in poorly controlled type 1 diabetes patients, Diabetes Technol Ther, 13, 657-60

Roger, B. *, J. Papin *, P. Vacher, M. Raoux, A. Mulot, M. Dubois, B.H. Vanderwalle, F. Pattou, G. Charpentier, J.C. Jonas, N. Moustaid-Moussa, and J. Lang, Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells. Diabetologia, 2011, 54:390-402.

F. Boal, M. Laguerre, A. Milochau, J. Lang and P. A. Scotti. A charged prominence in the linker domain of the cysteine-string protein CSPa mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis. FASEB J., 2011, 25:132-143.

Yassine, W., A. Milochau, S. Buchoux, J. Lang, B. Desbat, and R. Oda, Effect of monolayer lipid charges on the structure and orientation of protein VAMP1 at the air-water interface.  Biochem. Biophys. Acta – Biomembranes, 2010, 1798:928-937.

A. Ravaud, C. de la Fouchardiere, J. Asselineau, J. P. Delord, C. Do Cao, P. Niccoli, P. Rodien, M. Klein and B. Catargi, 2010, Efficacy of sunitinib in advanced medullary thyroid carcinoma: intermediate results of phase II THYSU, Oncologist, 15, 212-3;

Bornat, Y.; Raoux, M.; Boutaib, Y.; Morin, F. O.; Charpentier, G.; Lang, J.; Renaud, S. Detection of electrical activity of pancreatic ß-cells using micro-electrode arrays. Proceedings 5th  IEEE Int. Symposium on Electronic Design, Test & Applications, in press.

Yassine, W.,  Taib, N.,  Federman, S., Milochau, A., Castano, S., Sbi, W.,  Manigand, C.,  Laguerre, M., Desbat, B.,  Oda, R. and J. Lang, Reversible transition between a-helix and ß-sheet conformation of a transmembrane domain. Biochem. Biophys. Acta – Biomembranes20091788:1722-1730

Karaca, M,. Castel, J., Tourrel-Cuzin, C., Brun, M., Geant, A., Dubois, M., Catesson, S., Rodriguez, M., Luquet, S., Cattan, P., Lockhart, B., Lang, J., Ktorza A., Magnan, C. and C. Kargar, Exploring Functional ß-Cell Heterogeneity In Vivo Using PSA-NCAM as a Specific Marker. PLoS ONE, 2009, 4: e5555

Ravaine, V., C. Ancla, and B. Catargi, Chemically controlled closed-loop insulin delivery. J. Control. Release, 2008. 132: 2-11

Lapeyre, V., C. Ancla, B. Catargi, and V. Ravaine, Glucose-responsive microgels with a core-shell structure. J. Colloid Interface Sci., 2008. 327: 316-23.

Jeandidier, N., J.P. Riveline, N. Tubiana-Rufi, A. Vambergue, B. Catargi, V. Melki, G. Charpentier, and B. Guerci, Treatment of diabetes mellitus using an externalinsulin pump in clinical practice. Diabetes Metab., 2008. 34: 425-38.

Sa Cunha, A., C. Beau, A. Rault, B. Catargi, D. Collet, and B. Masson, Laparoscopic versus open approach for solitary insulinoma. Surg. Endosc., 2007. 21: 103-8

Grise, F., N. Taib, C. Monterrat, V. Lagrée, and J. Lang, Distinct roles of the C2A and the C2B domain of the vesicular Ca2+ sensor synaptotagmin 9 in endocrine ß-cells. Biochem. J., 2007, 403: p. 483-492.

Monterrat, C., F. Grise, A. Hémar, and J. Lang, The calcium-sensing protein synaptotagmin 7 is expressed on different endosomal compartments  in pancreatic ß-cells and in neurons but not on large dense core vesicles. Histochem. Cell Biol., 2007,127: 625-632.

Boal, F., S. Le Pevelen, C. Cziepluch, P. Scotti, and J. Lang, Cysteine-string protein isoform beta (Cspß) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal ß-cells. Biochim. Biophys. Acta - Mol. Cell Res., 2007. 1773: p. 109-119

Dubois, M., P. Vacher, B. Roger, D. Huyghe, B. Vandewalle, J. Kerr-Conte, F. Pattou, N. Moustaïd Moussa, and J. Lang, Glucotoxicity inhibits late steps of insulin exocytosis. Endocrinology, 2007. 148: p.1605-1614.

Lajus, S. and J. Lang, Splice variant 3, but not 2 of receptor protein-tyrosine phosphatase sigma can mediate stimulation of insulin-secretion by alpha-latrotoxin. J. Cell Biochem., 2006. 98: p. 1552-1559. 

Lajus, S., P. Vacher, D. Huber, M. Dubois, M.N. Benassy, Y. Ushkaryov, and J. Lang, Alpha-latrotoxin induces exocytosis by inhibition of voltage-dependent K+ channels and by stimulation of L-type Ca2+ channels via latrophilin in ß-cells. J. Biol. Chem., 2006. 281: p. 5522-5531

Monterrat, C., F. Boal, F. Grise, A. Hemar, and J. Lang, Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. Biochem. Biophys. Acta - Mol. Cell Res., 2006. 1763: p. 73-81.

Dufaitre-Patouraux, L., et al., Continuous intraperitoneal insulin infusion does not increase the risk of organ-specific autoimmune disease in type 1 diabetic patients:results of a multicentric, comparative study. Diabetes Metab., 2006. 32: 427-32.

Tabarin, A., et al., Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene". Diabetes, 2005. 54: 3510-6.

Gatta, B., D.H. Hau, B. Catargi, P. Roger, and A. Tabarin, Re-evaluation of the efficacy of the association of cabergoline to somatostatin analogues in acromegalic patients. Clin Endocrinol (Oxf), 2005. 63: 477-8.

Boal, F., H. Zhang, C. Tessier, P. Scotti, and J. Lang, The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions. Biochemistry, 2004. 43: p. 16212-16223   

Reviews

Renaud S, Catargi B, Lang J (2014) Biosensors in diabetes : how to get the most out of evolution and transpose it into a signal. IEEE pulse 5: 30-34

Schaepelynck P, Riveline JP, Renard E, Hanaire H, Guerci B, Baillot-Rudoni S, Sola-Gazagnes A, Catargi B, Fontaine P, Millot L, Martin JF, Tachouaft H, Jeandidier N, Group E (2014) Assessment of a new insulin preparation for implanted pumps used in the treatment of type 1 diabetes. Diabetes Technology & Therapeutics 16: 582-589

Benhamou PY, Catargi B, Delenne B, Guerci B, Hanaire H, Jeandidier N, Leroy R, Meyer L, Penfornis A, Radermecker RP, Renard E, Baillot-Rudoni S, Riveline JP, Schaepelynck P, Sola-Gazagnes A, Sulmont V, Tubiana-Rufi N, Durain D, Mantovani I, Sola-Gazagnes A, Riveline JP, EVdlDdIA (2012) Real-time continuous glucose monitoring (CGM) integrated into the treatment of type 1 diabetes: consensus of experts from SFD, EVADIAC and SFE. Diabetes & Metabolism 38 Suppl 4: S67-83

Verges B, Avignon A, Bonnet F, Catargi B, Cattan S, Cosson E, Ducrocq G, Elbaz M, Fredenrich A, Gourdy P, Henry P, Lairez O, Leguerrier AM, Monpere C, Moulin P, Verges-Patois B, Roussel R, Steg G, Valensi P,  (2012) Consensus statement on the care of the hyperglycaemic/diabetic patient during and in the immediate follow-up of acute coronary syndrome. Archives of Cardiovascular Diseases 105: 239-253

Raoux, M., G. Bontorin, Y. Bornat, J. Lang, and S. Renaud, Bioelectronic sensing of insulin demand, in Biohybrid Systems, R. Jung, Editor. 2011, Wiley-VCH.

Rigalleau, V., J. Lang, and H. Gin, Etiologie et physiopathologie du diabète de type 2. Encyclopédie Médico-chirurgicale, 2007.

Lang, J.
, Seconds messagers et exocytose. Médecine Clinique - Endocrinologie et Diabète, 2006. Nov 2006: p. 15-21.


Lang, J.
, PIPs and pools in insulin secretion. Trends Endocrinol. Metab., 2003. 14: p. 297-299.

Patents
Lang, J., S. Renaud, B. Catargi, M. Raoux, Y. Bornat, and G. Charpentier, Capteur pour la mesure des besoins d’insuline d’un patient et procédé de fabrication de celui-ci 13.1.2010: France N. 1050202 (PCT extension deposited)