entete
         
Jochen LANG

Original publications (57)

S. Saeed, A. Bonnefond, F. Tamanini, M. Mirza, J. Manzoor, Q. Janjua, S. Din, J. Gaitan, A. Milochau, E. Durand, E. Vaillant, A. Haseeb, F. De Graeve, L. Rabearivelo, O. Sand, G. Queniat, R. Boutry, D. Dina A Schott, H. Hina Ayesha, A. Muhammad Ali, W. Waqas I. Khan, T. Butt, T. Rinne, C. Stumpel, A. Abderrahmani, J. Lang, Arslan M, Froguel P, Loss-of-function mutations in ADCY3 cause monogenic severe obesity, Nat Genet, (in press).

D.A. Koutsouras, R. Perrier, A. Villaroel-Marquez, A. Pirog, E. Pedraza, E. Cloutet, S. Renaud, M. Raoux, G.G. Malliaras, J. Lang, Simultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays, Materials Science and Engineering: C, (IN PRESS)

Hastoy, B., P. A. Scotti, A. Milochau, Z. Fezoua-Boubegtiten, J. Rodas, R. Megret, B. Desbat, M. Laguerre, S. Castano, D. Perrais, P. Rorsman, R. Oda and J. Lang (2017). A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis. Scientific Reports 7(1): 2835.

Semplici, F., A. Mondragon, B. Macintyre, K. Madeyski-Bengston, A. Persson-Kry, S. Barr, A. Ramne, A. Marley, J. McGinty, P. French, H. Soedling, R. Yokosuka, J. Gaitan, J. Lang, S. Migrenne-Li, E. Philippe, P.L. Herrera, C. Magnan, G. da Silva Xavier, and G.A. Rutter. Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production. Diabetologia. 2016, 59:1938-47


Solomou, A., E. Philippe, P. Chabosseau, S. Migrenne-Li, J. Gaitan, J. Lang, C. Magnan, and G.A. Rutter.  Over-expression of Slc30a8/ZnT8 selectively in the mouse alpha cell impairs glucagon release and responses to hypoglycemia. Nutr Metab (Lond). 2016, 13:46.

Pedraza E, Karajić A, Raoux M, Perrier R, Lebreton F, Arbault S, Gaitan J, Renaud S, Kuhn A, Lang, J (in press). Guiding pancreatic beta-cells to target electrodes in a whole-cell biosensor for diabetes.Lab Chip, 2015, DOI: 10.1039/C5LC00616C.

Lebreton F, Pirog A, Belouah I, Bosco D, Berney T, Meda P, Bornat Y, Catargi B, Renaud S, Raoux M, Lang J. Slow potentials encode intercellular coupling and insulin demand  in pancreatic beta cells.
Diabetologia 2015, 58:1291-9

M. Raoux, P. Vacher, J. Papin, A. Picard, E. Kostrzewa, A. Devin, J. Gaitan, I. Limon, M. J. Kas, C. Magnan , J. LangMultilevel control of glucose homeostasis by adenylyl cyclase 8Diabetologia  2015, 58:749-757

H. Dou, C.Wang, X. Wu, L. Yao, X. Zhang, S. Teng, H. Xu, B. Liu, Q. Wu, Q. Zhang, M. Hu, Y. Wang, L. Wang, Y. Wu, S. Shang, X. Kang, L. Zheng, J. Zhang, Raoux M., Lang J., Q. Li, J. Su, X. Yu, L. Zhou.
Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia 2015, 58:324-333.

Milochau, A., Lagrée, V., Bennassy, M.N., Papin, J., Lajoix, A., Chaignepain, S., Garcia-Arcos, I., Schmitter, J.M., Ochoa, B. and Lang, J. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic ß-cells.
FEBS Lett.  2014, 588:2217-2222.

Nguyen, Q.V., Caro, A., Raoux, M., Quotb, A., Floderer, J.B., Bornat, Y., Renaud, S. and Lang, J. (2013). A novel bioelectronic glucose sensor to process distinct electrical activities of pancreatic beta-cells. Conf Proc IEEE Eng Med Biol Soc 2013, 172-175. 

A. Quotb, Bornat Y, Raoux M, Lang J, Renaud S. NeuroBetaMed: A re-configurable wavelet-based event detection circuit for in vitro biological signals. 2012 IEEE International Symposium on Circuits and Systems (ISCAS), Seoul, Korea (South). 2012.

Raoux, M.,  Bornat, Y., Quotb, A., Catargi, B., Renaud, S. and  Lang , J.  Non-invasive long-term and real-time analysis of endocrine cells on micro-electrode arrays. J. Physiol. 2012, 590:1085-1092.

Roger, B. *, J. Papin *, P. Vacher, M. Raoux, A. Mulot, M. Dubois, B.H. Vanderwalle, F. Pattou, G. Charpentier, J.C. Jonas, N. Moustaid-Moussa, and J. Lang, Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells. Diabetologia, 2011, 54:390-402.

F. Boal, M. Laguerre, A. Milochau, J. Lang and P. A. Scotti. A charged prominence in the linker domain of the cysteine-string protein CSPa mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis. FASEB J., 2011, 25:132-143.

Yassine, W., A. Milochau, S. Buchoux, J. Lang, B. Desbat, and R. Oda, Effect of monolayer lipid charges on the structure and orientation of protein VAMP1 at the air-water interface.  Biochem. Biophys. Acta – Biomembranes, 2010, 1798:928-937.

Bornat, Y.; Raoux, M.; Boutaib, Y.; Morin, F. O.; Charpentier, G.; Lang, J.; Renaud, S. Detection of electrical activity of pancreatic http://www.betacell-cellbio.eu/publications.htmlß-cells using micro-electrode arrays. Proceedings 5th  IEEE Int. Symposium on Electronic Design, Test & Applications, 2010.

Yassine, W.,  Taib, N.,  Federman, S., Milochau, A., Castano, S., Sbi, W.,  Manigand, C.,  Laguerre, M., Desbat, B.,  Oda, R. and J. Lang, Reversible transition between a-helix and ß-sheet conformation of a transmembrane domain. Biochem. Biophys. Acta – Biomembranes, 2009, 1788:1722-1730.

Karaca, M,. Castel, J., Tourrel-Cuzin, C., Brun, M., Geant, A., Dubois, M., Catesson, S., Rodriguez, M., Luquet, S., Cattan, P., Lockhart, B., Lang, J., Ktorza A., Magnan, C. and C. Kargar, Exploring Functional ß-Cell Heterogeneity In Vivo Using PSA-NCAM as a Specific Marker. PLoS ONE, 2009, 4: e5555

Grise, F., N. Taib, C. Monterrat, V. Lagrée, and J. Lang, Distinct roles of the C2A and the C2B domain of the vesicular Ca2+ sensor synaptotagmin 9 in endocrine ß-cells. Biochem. J., 2007, 403: p. 483-492.

Monterrat, C., F. Grise, A. Hémar, and J. Lang, The calcium-sensing protein synaptotagmin 7 is expressed on different endosomal compartments  in pancreatic ß-cells and in neurons but not on large dense core vesicles. Histochem. Cell Biol., 2007,127: 625-632. 

Boal, F., S. Le Pevelen, C. Cziepluch, P. Scotti, and J. Lang, Cysteine-string protein isoform beta (Cspß) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal ß-cells. Biochim. Biophys. Acta - Mol. Cell Res., 2007. 1773: p. 109-119.

Dubois, M., P. Vacher, B. Roger, D. Huyghe, B. Vandewalle, J. Kerr-Conte, F. Pattou, N. Moustaïd Moussa, and J. Lang, Glucotoxicity inhibits late steps of insulin exocytosis. Endocrinology, 2007. 148: p.1605-1614.

Lajus, S. and J. Lang, Splice variant 3, but not 2 of receptor protein-tyrosine phosphatase sigma can mediate stimulation of insulin-secretion by alpha-latrotoxin. J. Cell Biochem., 2006. 98: p. 1552-1559. 

Lajus, S., P. Vacher, D. Huber, M. Dubois, M.N. Benassy, Y. Ushkaryov, and J. Lang, Alpha-latrotoxin induces exocytosis by inhibition of voltage-dependent K+ channels and by stimulation of L-type Ca2+ channels via latrophilin in ß-cells. J. Biol. Chem., 2006. 281: p. 5522-5531.

Monterrat, C., F. Boal, F. Grise, A. Hemar, and J. Lang, Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. Biochem. Biophys. Acta - Mol. Cell Res., 2006. 1763: p. 73-81.

Boal, F., H. Zhang, C. Tessier, P. Scotti, and J. Lang, The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions. Biochemistry, 2004. 43: p. 16212-16223

Zhang, H., K.W. Peters, F. Sun, C.R. Marino, J. Lang, R.D. Burgoyne, and R.A. Frizzell, Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator. J. Biol. Chem., 2002. 277: p. 28948-28958. 

Gut, A., C.E. Kiraly, M. Fukuda, K. Mikoshiba, C.B. Wollheim, and J. Lang, Expression and localisation of synaptotagmin isoforms in endocrine beta-cells: their function in insulin exocytosis. J. Cell Sci., 2001. 114: p. 1709-1716.

Hashimoto, Y., T. Niikura, H. Tajima, T. Yasukawa, H. Sudo, Y. Ito, Y. Kita, M. Kawasumi, K. Kouyama, M. Doyu, G. Sobue, T. Koide, S. Tsuji, J. Lang, K. Kurokawa, and I. Nishimoto, A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aß. Proc. Nat'l Acad. Sci. U S A, 2001. 98: p. 6336-6341. 

Zhang, H., W.L. Kelley, L.H. Chamberlain, R.D. Burgoyne, and J. Lang, Mutational analysis of cysteine-string protein function in insulin exocytosis. J. Cell Sci., 1999. 112: p. 1345-1351.

Lang, J., Y. Ushkaryov, A. Grasso, and C.B. Wollheim, Ca2+-independent insulin exocytosis induced by a-latrotoxin requires latrophilin, a G protein-coupled receptor. EMBO J., 1998. 17: p. 648-657.

Zhang, H., W.L. Kelley, L.H. Chamberlain, R.D. Burgoyne, C.B. Wollheim, and J. Lang, Cysteine-string proteins regulate exocytosis of insulin independent from transmembrane ion fluxes. FEBS Lett., 1998. 437: p. 267-272.

Zhang, H., H. Yasrebi-Nejad, and J. Lang, G-protein ßg-binding domains regulate insulin exocytosis in clonal pancreatic ß-cells. FEBS Lett., 1998. 424: p. 202-206.

Lang, J., M. Fukuda, H. Zhang, K. Mikoshiba, and C.B. Wollheim, The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium. EMBO J., 1997. 16: p. 5837-5846.

Lang, J., H. Zhang, V.V. Vaidyanathan, K. Sadoul, H. Niemann, and C.B. Wollheim, Transient expression of botulinum neurotoxin C1 light chain differentially inhibits calcium and glucose induced insulin secretion in clonal ß-cells. FEBS Lett., 1997. 419: p. 13-17.

Mohlig, M., S. Wolter, P. Mayer, J. Lang, M. Osterhoff, P.A. Horn, H. Schatz, and A. Pfeiffer, Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles. Endocrinology, 1997. 138: p. 2577-2584.

Kiraly-Borri, C.E., A. Morgan, R.D. Burgoyne, U. Weller, C.B. Wollheim, and J. Lang, Soluble N-ethylmaleimide-sensitive-factor attachment protein and N-ethylmaleimide-insensitive factors are required for Ca2+-stimulated exocytosis of insulin. Biochem. J., 1996. 314 ( Pt 1): p. 199-203.

Regazzi, R., M. Ravazzola, M. Iezzi, J. Lang, A. Zahraoui, E. Andereggen, P. Morel, Y. Takai, and C.B. Wollheim, Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. J. Cell Sci., 1996. 109: p. 2265-2273.

Lang, J., I. Nishimoto, T. Okamoto, R. Regazzi, C. Kiraly, U. Weller, and C.B. Wollheim, Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and Go or by the expression of their active G alpha subunits. EMBO J., 1995. 14: p. 3635-3644.

Regazzi, R., C.B. Wollheim, J. Lang, J.M. Theler, O. Rossetto, C. Montecucco, K. Sadoul, U. Weller, M. Palmer, and B. Thorens, VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca2+-but not for GTP gamma S-induced insulin secretion. EMBO J., 1995. 14: p. 2723-2730.

Sadoul, K., J. Lang, C. Montecucco, U. Weller, R. Regazzi, S. Catsicas, C.B. Wollheim, and P.A. Halban, SNAP-25 is expressed in islets of Langerhans and is involved in insulin release. J. Cell Biol., 1995. 128: p. 1019-1028.

Juge-Aubry, C.E., H. Liang, J. Lang, J.W. Barlow, and A.G. Burger, Synthesis and characterization of anti-idiotypic anti-T4 antibodies. Eur. J. Endocrinol., 1994. 130: p. 107-112.

Kiss, J.Z., C. Wang, S. Olive, G. Rougon, J. Lang, D. Baetens, D. Harry, and W.F. Pralong, Activity-dependent mobilization of the adhesion molecule polysialic NCAM to the cell surface of neurons and endocrine cells. EMBO J., 1994. 13: p. 5284-5292.

Lang, J., F. Boulay, P. Parker, P. Gierschik, and C.B. Wollheim, Regulation of cytosolic calcium and insulin secretion by galanin and ATP receptors: interactions of pertussis-toxin-sensitive and -insensitive signalling pathways. Biochem. J., 1994. 303 ( Pt 3): p. 885-891.

Lang, J., F. Boulay, G. Li, and C.B. Wollheim, Conserved transducer coupling but different effector linkage upon expression of the myeloid fMet-Leu-Phe receptor in insulin secreting cells. EMBO J., 1993. 12: p. 2671-2679.

Ammer, H., L. Nice, J. Lang, and R. Schulz, Regulation of G proteins by chronic opiate and clonidine treatment in the guinea pig myenteric plexus. J. Pharmacol. Exp. Ther., 1991. 258: p. 790-796.

Costa, T., J. Lang, C. Gless, and A. Herz, Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions. Mol. Pharmacol., 1990. 37: p. 383-394.

Lang, J., Purification and characterization of subforms of the guanine-nucleotide-binding proteins G alpha i and G alpha o. Eur. J. Biochem., 1989. 183: p. 687-692.

Lang, J. and T. Costa, Chronic exposure of NG 108-15 cells to opiate agonists does not alter the amount of the guanine nucleotide-binding proteins Gi and Go. J. Neurochem,. 1989. 53: p. 1500-1506.

Lang, J. and T. Costa, Chronic naloxone treatment of NG 108-15 cells alters the function but not the amount of pertussis toxin substrates. Adv. Biosci., 1989. 75: p. 703-706.

Lang, J. and R. Schulz, Chronic opiate receptor activation in vivo alters the level of G-protein subunits in guinea-pig myenteric plexus. Neuroscience, 1989. 32: p. 503-510.

Lang, J. and T. Costa, Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o. J. Recept. Res., 1989. 9: p. 313-329.

Toselli, M., J. Lang, T. Costa, and H.D. Lux, Direct modulation of voltage-dependent calcium channels by muscarinic activation of a pertussis toxin-sensitive G-protein in hippocampal neurons. Pflugers Arch., 1989. 415: p. 255-261.

Lang, J. and T. Costa, Antisera against the 3-17 sequence of rat G alpha i recognize only a 40 kDa G-protein in brain. Biochem. Biophys. Res. Commun., 1987. 148: p. 838-848.

Przewlocki, R., T. Costa, J. Lang, and A. Herz, Pertussis toxin abolishes the antinociception mediated by opioid receptors in rat spinal cord. Eur. J. Pharmacol, 1987. 144: p. 91-95.

Starke, K., L. Spath, J.D. Lang, and C. Adelung, Further functional in vitro comparison of pre- and postsynaptic dopamine receptors in the rabbit caudate nucleus. Naunyn Schmiedebergs Arch Pharmacol, 1983. 323: p. 298-306.

 

Reviews  (7)

B. Hastoy, A. Clark, P. Rorsman, J. Lang, Fusion pore in exocytosis: more than an exit gate?   A b-cell perspective, Cell Calcium, (in press).

Renaud S, Catargi B, Lang J., Biosensors in Diabetes: How to get the most out of evolution and transpose it into a signal. IEEE Pulse. 2014,  5:30-4. doi: 10.1109/MPUL.2014.2309577.

Rigalleau, V., J. Lang, and H. Gin, Etiologie et physiopathologie du diabète de type 2. Encyclopédie Médico-chirurgicale, 2007, in press.

Lang, J., PIPs and pools in insulin secretion. Trends Endocrinol. Metab., 2003. 14: p. 297-299.

Lang, J., Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur. J. Biochem., 1999. 259: p. 3-17.

Wollheim, C.B., J. Lang, and R. Regazzi, Regulation of exocytosis by Ca2+ and G-proteins. Diabetes Rev., 1996. 4: p. 277-297.

Wollheim, C.B. and J. Lang, A game plan for exocytosis. Trends Cell Biol., 1994. 4: p. 339-341.

 

Book Chapters  (3)

Raoux, M., G. Bontorin, Y. Bornat, J. Lang, and S. Renaud, Bioelectronic sensing of insulin demand, in Biohybrid Systems, R. Jung, Editor. in press, Wiley-VCH.

Lang, J., R. Regazzi, and C.B. Wollheim, Clostridial toxins and endocrine secretion: Their use in insulin-secreting cells, in Bacterial toxins: tools in cell biology, K. Aktories, Editor. 1997, Chapman & Hall: Weinheim. p. 217-240.

Lang, J., Guanine nucleotide binding proteins and their coupling to opioid receptors, in Neurobiology of Opioids, O.F.X. Almeida and T.S. Shippenberg, Editors. 1990, Springer: Heidelberg. p. 121-140.

 

Patents (1)

Lang, J., S. Renaud, B. Catargi, M. Raoux, Y. Bornat, and G. Charpentier, Capteur pour la mesure des besoins d’insuline d’un patient et procédé de fabrication de celui-ci 13.1.2010: France N. 1050202 (PCT extension WO/2011/086105 )