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RESEARCH PROJECTS  


Type 2 diabetes, a lifelong, incapacitating disease, affects 5% of the population in Europe and its complex aetiology includes alterations of pancreatic -cells and insufficient insulin secretion as an important facet.
 
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Insulin-secreting
pancreatic
-cells and islets  play a major role in nutrient homeostasis and provide a powerful model to dissecate mechanisms and regulation of vesicular transport and fusion with the plasma membrane.
Our studies on  pancreatic -cells have three major goals:

1. Gaining insight in the interplay between proteins at different stages of exocytosis and regulatory events, understanding the interactions in physicochemical terms in membranes and at the membrane/cytosol interface. READ MORE.

2. Investigate the regulation of -cells, glucose signalling,   the contribution of exocytotic proteins to diabetic syndromes. READ MORE.

3. Develop the use of extracellular recordings of pancreatic islets as device for pre-transplantation  quality control, drug screening  and long-term experiences (DiachipTM).  This project run in close collaboration with the Dept. of Microelectronics and Clinical Diabetology, serves also as base for a novel bioelectronic sensor for the demand in insulin to be used in an artificial pancreas (DiasensorTM). READ MORE.

We use different means of biochemistry, molecular cell biology, imaging, electrophysiology and functional genomics on clonal or primary -cells derived from islets (rat, murine). We have recently embarked on the use of transgenic models.
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