in Diabetes
Hybrid Biosensors:
Last Publications:
Gluk2 kainate receptor and glucose homeostasis Mol Met, in press
The transmembrane domain of the SNARE protein VAMP2 is highly sensitive to its lipid environment. BBA Biomembranes 1861, 670-676 (2019).
Bioelectronic organ-based sensor for microfluidic real-time analysis of the demand in insulin. Biosens Bioelectron 117, 253-259 (2018)
Loss-of-function mutations in ADCY3 cause monogenic severe obesity, Nat Genet, 50, 175-179, (2018)
A central small amino acid in the VAMP2 transmembrane domain regulates the fusion pore in exocytosis. Scientific Reports 7, Article number: 2835 (2017).
Fusion pore in exocytosis: More than an exit gate? A β-cell perspective; Cell Calcium, 68, 45-61 (2017)

Last Talks/Posters (EASD 2018):
M. RAOUX  In-silico use of biosensor signals
M. Jaffredo    Electric Biphasic signals
M. Abarkan  GLUK2 and glucose homeostasis

Our research group, set up in 2003 as "Jeune Equipe", ipart of the UMR CNRS 5248 (CBMN) since 2007 and of the University of Bordeaux , Faculty of Biology. Our laboratory is  affiliated with the doctoral school "Life and Health Sciences". 
Our main research topics are transport phenomena in pancreatic ▀-cells (traffic, exocytosis), their alteration in pathological states (diabetes). We are interested in structure and function of transmembrane proteins, cell signalling and adaptation.
More recently we have started work on hybrid bioelectronic sensors We use means of molecular cell biology, biochemistry and electrophysiology.
In terms of teaching we provide a number of courses in biochemistry, cellular and molecular biology as well as physiology at the undergraduate and at the graduate level.


Contact: Contact:   Groupe Lang; UniversitÚ de Bordeaux 1, UMR CNRS 5248
Av St Hilaire,  F-33607 PESSAC  France,

Use FIREFOX for best visualisation of these pages